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Imovie windows xp download1/21/2024 ![]() ![]() If you have a third-party wireless network adapter, make sure that the device is supported by Windows XP SP3, or make sure that the manufacturer of your wireless network adapter has new drivers available that support Windows XP SP3 before you perform the installation. If you have a third-party wireless network adapter, make sure that it is supported To uninstall these updates, follow these steps:Ĭlick Microsoft Shared Computer Toolkit or Remote Desktop Connection.įor more information, click the following article number to view the article in the Microsoft Knowledge Base:ĩ49388 Windows XP Service Pack 3 installation fails with an error message, and the following error is logged in the service pack installation log: "8007F0F4 - STATUS_PREREQUISITE_FAILED" If one or both updates are installed on your computer, remove these updates before you install Windows XP SP3. Remote Desktop Connection (RDP) 6.0 MUI pack (Update 925877 for Windows XP) Windows XP SP3 cannot be installed if you have the following updates installed on your computer: If you have the following updates on your computer, remove them To install Windows XP SP3 from a CD, we recommend that you have about 1,765 MB of free space.įor more information about hard disk requirements, click the following article number to view the article in the Microsoft Knowledge Base:ĩ47311 The hard disk space requirements for Windows XP Service Pack 3 To install Windows XP SP3 from a shared network folder, we recommend that you have about 1,100 MB of free space. To install Windows XP SP3 from the Microsoft Download Center, we recommend that you have a minimum of 1,500 megabytes (MB) of free space on the system disk. More Information Prerequisites to install Windows XP SP3īefore you start to install Windows XP SP3, make sure that your computer meets the following prerequisites:īefore you download or install Windows XP SP3, first check hard-disk spaceĭepending on where you obtain Windows XP SP3, you will have to have a minimum amount of space free on the system disk. In addition, this article can help you troubleshoot some common error messages that you may receive when you install Windows XP SP3. Other than these prerequisites, this article also provides some suggestions to improve your experience. This article gives you the prerequisites to install Windows XP SP3. To make sure that you have a good experience when you install Windows XP Service Pack 3 (SP3), it is always good to check whether your computer is ready for Windows XP SP3. If you implement this workaround, take any appropriate additional steps to help protect the computer. Before you make these changes, we recommend that you evaluate the risks that are associated with implementing this workaround in your particular environment. You can make these changes to work around a specific problem. Other perks include vast libraries of effects, transitions, titles, and music tracks.Important This article contains information that shows you how to help lower security settings or how to turn off security features on a computer. This freeware for Windows 11, Windows 10 and older has it all - video and audio editing instruments, enhancing tools, a Chroma Key feature. Love Apple iMovie for its rich toolkit? Then you’ll have a blast with Clipify. Why is Clipify the Perfect Windows Version of iMovie? And it certainly doesn’t hurt that the software is free to download and use. It works well even on older computers and is compatible with Windows 7, 8, 10, and 11. So if you need a reliable and robust desktop program to create family movies, YouTube tutorials, or videography pieces, Clipify is the right tool for the job. You just need Clipiy, a free iMovie alternative for Windows.Ĭlipify is as close to iMovie as you can get - both in terms of workflow and toolkit. Are you a PC user but still want to create movies with no effort? Don’t worry, there is a solution for you. Its major downside, however, is that it is only available for Mac. It is easy and intuitive yet feature-packed. Is There a Decent iMovie for Windows? There Is! ![]()
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New american finance1/21/2024 ![]() ![]() Please appreciate that there may be other options available to you than the products, providers or services covered by our service. Worst experience ever Never touched base, completely ignored phone and email We had to go through the main number just to get a response. compares a wide range of products, providers and services but we don't provide information on all available products, providers or services. We refinanced our house with American We refinanced our house with American finance 3 times and the last 2 times was with the same person jason vigil. The international footprint of entities like Citigroup and AIG underlines the U.S. NEW AMERICAN FUNDING, 690 OTAY LAKES ROAD, SUITE 100. American Express and Goldman Sachs, with their extensive history, symbolize the fusion of traditional financial services with modern innovations, maintaining relevancy in the ever-evolving sector. NMLS 6606 New American Funding (NAF) - India, is the subsidiary of New American Funding Inc., one of the largest privately-owned direct. Please don't interpret the order in which products appear on our Site as any endorsement or recommendation from us. AMERICAN FAMILY FUNDING, 28015 SMYTH DRIVE SANTA CLARITA, CA 91355 661.284. NAF Technology India 2,644 followers on LinkedIn. While compensation arrangements may affect the order, position or placement of product information, it doesn't influence our assessment of those products. We may also receive compensation if you click on certain links posted on our site. We may receive compensation from our partners for placement of their products or services. Many customers were frustrated with having to verify their. While we are independent, the offers that appear on this site are from companies from which receives compensation. However, a common complaint from reviewers for New American Funding is the underwriting process. All international money transfer servicesį is an independent comparison platform and information service that aims to provide you with the tools you need to make better decisions.Session: AFFECT Mentoring Event (by invitation only) Janu8:00 to 17:00 Location: Sheraton: Oak Alley (4th Floor) Session type: invited. ![]() American Finance Association 2023 Annual Meeting. Best debt consolidation loans of October 2023 74 sessions, 242 papers, and 11 presentations with no associated papers. ![]()
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Pastor wilson response1/20/2024 ![]() ![]() She has a whole lifetime of growing up in an abusive home and has been generally treated badly by almost everyone in her life, so of course those facts contribute greatly to the situation. During these bouts, she also says she is no longer a believer, doesn’t believe in God, thinks God is out to get her. She made a profession of faith a few years ago and has been baptized in our local church, and except for these bouts I would have no reason to question any of that. She alternates between bouts of depression, rage, hurling insults and profanities at me, making ridiculous accusations against the church and God, to beating against the walls and causing damage to our house, and then later expression deep remorse and deep sorrow over her words and actions. My wife is having what you might call a “crisis of faith”. But many people simply say that it isn’t a necessary qualification.Īll of this to say, I’m curious your thoughts on the need for an elder candidate to be married and what we are looking at in regards to his children in light of Titus 1:6. They are 2 and 3, not unreasonably disobedient or bad kids by any means, but I don’t know how to evaluate Titus 1:6 as a qualification without requiring them to have credible profession of faith. But the only thing he lacks is that I’m not sure his kids are faithful/believers (Titus 1:6). ![]() He has all the qualifications found in Timothy and Titus even being married. I’m examining these things because my church is considering putting a young man into the role of elder who is 25 years old. (Matthew Henry simply says “not that ministers must be married this is not meant”) I don’t understand how it is such a common view to allow ministers to be unmarried. I’ve been reading online discussions on the matter (puritanboard) and some commentaries and most of the arguments simply sweep it away without argument. Namely my view is that it is necessary for someone to be married and to have children who are faithful/believers (Titus 1:6). I recognize that I’m a minority position (even historically) but I can’t get past what seems to be the clear reading of Timothy and Titus. I’m wrestling with the passages about elder qualifications. Do you ever feel like you’re contributing to the attention deficit problem? Or is it more important to reach people where they are despite the contribution? But there’s short Youtube clips, social media accounts, etc. Your church seemed to go with a bit of both. Reaching them where we wish they were has the likelihood of not reaching them at all. Reaching people where they are has the potential for being ‘seeker-sensitive’ and being a contributor to the attention span problem. Do I reach people where they are (social media), or do I reach them where I wish they were (books, sermons). So for any ministry, there’s a decision to be made. No one seems to have the patience to ever read a book anymore. Everyone’s attention span is shot and it’s doing real damage to the younger generations. I firmly believe that the combination of the smartphone and social media (Twitter, Youtube, TikTok) have turned our society into a group that can’t stand to not be looking at their phones. And then bury the slag in a smoking landfill. What fun it would be to topple over that idol in the Name of the Lord! And then chop it into little pieces-the kind of pieces our babies must endure. But He preserves a faithful remnant who will not bow the knee to the State or its gods, sacrifice our kids (literally or metaphorically), or refuse to love the Lord with all our heart, soul, mind, and strength.Īs to this specific atrocity, I wonder if we could gather a coalition of black-hooded blokes to climb atop that courthouse, spray paint that demonic image with a huge red Cross, and then rip it down as they sing Psalm 68 at the top of their voices. So, God is destroying America for our gross and hideous sins. But never forget that while God was utterly destroying Israel for gross and hideous sins-idolatry, child sacrifice, whoredom, sodomy, etc.-He promised a distraught Elijah there were a few thousand faithful who had not and would not bow the knee to Baal. I suspect there are times when you, Pastor, feel like you’re the only one hitting that fire alarm. the lump that forms in my throat is large and suffocating. When my “To the Word” morning reading highlights the standoff between Elijah and the 450 prophets of Baal, and then I come across this. ![]()
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Discount disney vacation packages1/20/2024 ![]() ![]() Not only are there a bunch of new attractions to enjoy if you haven’t been for a few years, but combine that with the low crowd levels and deep discounts currently being offered and it’s a perfect storm of sorts. ![]() If you are in the market for a Walt Disney World vacation, 2024 is an amazing year to go. This had now led to some nice discounts for early 2024 and we expect there to be more throughout next year too. Hotel reservations are down through the rest of the year and even into next year, and that’s why Disney has upped its “discount game”, hoping to entice would-be-travelers who are currently on the fence. Crowd levels are 20%-30% lower at this time than they were just last year, which is excellent if you are looking for short lines for your favorite attractions.Īnd it’s also starting to show up in a lack of future bookings. If you have been to the parks in 2023, it’s really night and day. residents are not spending nearly as much this year on travel in general, and many are cutting back on expenses due to the unstable economic situation. Last year, there were a ton of pent-up travelers who hadn’t been to Disney World in a few years, and they were flocking to the parks in almost record numbers. Honestly, with the number of people that visited Walt Disney World in 2022, we didn’t think that there would be so many good promotions in 2023. Best Way to Save Big $$$ on Disney Resortsīargain shoppers will be happy to know that there are some truly amazing discounts currently running at Walt Disney World, much more so than all of last year, and some of the offers are the best ones we’ve seen in 4-5 years!.Ready to Start Planning Your Disney Vacation?.That’s one of the reasons we highly recommend using an Authorized Disney Travel Planner to do the hard work for you. They are full of great tips to help you do Disney as cheaply as possible.ĭisney World discounts are not always easy to get, and they are usually limited to a certain number of guests, so you will need to be quick! They are also hard to understand and are not always straightforward. Military members, Visa Cardholders, and whatever other offers pop up.Īlong with this post, you will also want to read our two guides on saving money at Disney World. In this post, I will explain all the latest Walt Disney World discounts including for the general public, Annual Passholders, Florida Residents, Disney+ subscribers, U.S. To help make finding the latest offers and specials easier for you, I decided to put all the current Disney World discounts in one place so you can compare which ones are the best for you and offer the most savings. Everyone would love to save money on their Walt Disney World vacation, and thankfully, from time to time, Disney offers special promotions and discounts to help guests save money on a vacation package, hotel rooms, tickets, dining, and more. ![]()
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Mp4 to wmv converter1/20/2024 ![]() ![]() MP4, a short form for MPEG-4 Part 14, is a versatile video file format that is widely used for storing and transmitting multimedia content. With its efficient compression algorithm, WMV files are used for web-based video content, video presentations, and even high-definition movies. Due to its small file size and high video quality, it is widely used for online video streaming and downloading. This only means to say that it is useful on the part of the users.īut if you don't want to limit the conversion speed because of the internet speed, or want to save time to convert videos in batch, you'd better use Wondershare UniConverter instead, download and have a try now.WMV (Windows Media Video) is a well-known video file format developed by Microsoft. This does not only convert files to WMV format. Step 4 As long as you have agreed to the terms and conditions, you may now decide to convert your file.Īnother impressive thing to love about this online conversion tool is that it can convert MP4 files to any other format. Step 3 You have to enter the email address in order that you can receive your converted files. Step 2 You need to choose the format that you like your files to be converted to. Step 1 You are first required to choose URL or files to convert for up to 50MB of files. This way, you can make use of it for your utmost ease and convenience. In using this online solution, following a few of the simple steps are essential. As this is introduced for free online, this is something that you should not miss out on. ![]() You can do the conversion of your file anytime and anywhere. This simply lets you convert MP4 to WMV with ease and convenience. The ZAMZAR free online file converter is simply a great tool to use. This online solution should be able to convert MP4 to WMV properly. ![]() Through the use of an online solution, you can simply do this easily. ![]() Online Solution to Convert MP4 to WMV on Macĭue to the reason that you sometimes need an uncompressed video for the best viewing experience, it is best to have a converter that translates files right from MP4 to WMV. This is especially when it comes to a time that WMV files need to be played on Mac. In WMV format, it mainly requires the use of plug-ins such as the Flip4Mac. This is especially in terms of editing the MP4 videos. When it comes to their disadvantages, the MP4 requires system resources. But then, this is even more compatible with Windows PC. The WMV format is smaller in its file size as compared to MP4. This is also commonly used to share video files online. The advantages of MP4 audio include better video quality and support by mobile, OS, and player devices. This also aims to improve and duplicate its functionality for the users. On the other hand, the WMV format is entirely based on the MPEG4 standard. The file format also defines the storage of MPEG-4 audio, multimedia content, and scenes through the use of ISO based media file format. For instance, the former is a method that defines the compression of visual and audio digital data. The MP4 and WMV formats are exactly different from each other. Watch Video Tutorial to Convert MP4 to WMV on Windows 10 And after a while, you can get the converted file in the Finished tab. Step 4 You can now convert MP4 to WMV on Mac.Ĭlick the Convert button to start the MP4 to WMV conversion. And choose the target format WMV through Video > WMV > the resolution. Step 3 Select the output format WMV for MP4 to WMV Mac conversion.Ĭlick the Setting icon to enter the format panel. Step 2 Load MP4 files to the Mac MP4 converter.Ĭlick the Add Files button to add MP4 files by browsing the target folder, and choose the MP4 files you want to convert to WMV, and then click the Load button to go ahead. Step 1 Download the Mac MP4 to WMV converter.ĭownload, install and launch Wondershare UniConverter for Mac on your Mac. Using Wondershare UniConverter, following the simple guides below to convert MP4 to WMV on Mac is essential. Versatile toolbox combines video metadata editor, GIF maker, video compressor, and screen recorder ![]()
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![]() ![]() Despite the fact that this chapter is about derivatives we will start out the chapter with a section on limits of functions of. However, the chain rule for the total derivative takes such dependencies into account. ![]() In Calculus III we will extend our knowledge of calculus into functions of two or more variables. The partial derivative of f with respect to x does not give the true rate of change of f with respect to changing x because changing x necessarily changes y. ![]() A collection of examples, animations and notes on Multivariable Calculus. Compute derivatives using the chain rule. In Calculus I and in most of Calculus II we concentrated on functions of one variable. Second Derivative Third Derivative Higher Order Derivatives Derivative at a point. You must use the Chain rule to find the derivative of any function that is comprised of one function inside of another function.In calculus, the chain rule is a formula that expresses the derivative of the composition of two differentiable functions f and g in terms of the derivatives of f and g. Chain Rule for Second Order Partial Derivatives. In mathematics, a partial derivative of a function of several variables is its derivative with respect to one of those variables, with the others held constant (as opposed to the total derivative, in which all variables are allowed to vary).Partial derivatives are used in vector calculus and differential geometry. As you explore more about partial derivatives, youll encounter a key rule frequently used in calculus-The Chain Rule. Free Derivative Chain Rule Calculator - Solve derivatives using the charin rule method step-by-step. ![]()
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Doom 2 steam overlay1/20/2024 ![]() I've tested with vsync off so the hz doesn't matter. Steam overlay works perfectly for me and a lot of others also in DOOM Eternal. Those who say don't, simply can't notice it, never compared with and without, or are not influenced by the decrease because maybe the overlay does not influence the framerate so much as to go below the maximum framerate rendered by the screen (if I were to play in 16:9 1080p or 1440p 60 Hz I very probably would not notice any drop with the overlay activated because at those res I would have 130+ fps, so if the overlay eats even 50 fps from those 140, would still be rock solid 60 fps at 60 Hz). Depois de instalar o seu Source port favorito, precisamos ir sua biblioteca de jogos da Steam, clicar no Doom II: Hell on Earth com o boto direito do mouse.Ento v para a aba propriedades, entre em SET LAUNCH OPTIONS(Definir opes de inicializao). Not everybody has issues = wrong (we are still talking about Doom Eternal and not games in general). If you open appinfo.vdf (in the appcache folder) with Notepad++, use ctrl + f to look for 'doom2.bat', and then replace it with dosbox.exe (you can do the same with 'doom2 + mouse.bat' as well). ![]() And with "always decrease" I meant obviously in doom eternal, not in every game. To be honest, I used Notepad++ instead of a hex editor, and doing it this way is much easier in my opinion. As such, disable for now, or perhaps forever-it's just a menu screen. Steam overlay is tethered to that setting but not utilizing it appropriately. Then go to display settings 'use hdr' -> 'on' and 'stream hdr video' -> 'off'. ![]() Geforce experience overlay (screenshots, instant replay, video etc) and steam overlay (or any other overlay) won't work with Doom Eternal. To temporarily fix this issue (assuming you're using windows), open start menu and type 'windows hd color settings'. Sounds like you have several issues besides the overlay if you cannot even get GE to work. From my recollection, the Steam overlay will still pass through to ZDoom or GZDoom through whatever launcher you use. The Steam overlay, which is required for proper Steam Controller usage, injects itself into the render pipeline of the game, in this case, DOSbox. Sometimes, as far as steam is concerned it is only getting one or less than one frame per second. Overlays will not "always decrease" your fps. The problem arises in how the steam overlay interacts with only partial updates. The game doesn't even have an option to take screenshots in game.geforce experience also is not working. The reason for this is: Doom 2 launches from a. It's horrible because I use the overlay to reply in whatsapp (or chat on steam) and take screenshots (I love taking screenshots). Intro You may notice Steam Overlay does not work for Doom 2, even though it does for Doom 1. I do rock solid 100 without overlay and I have drops to 80 or even 40-50 in some spots, if I use the overlay. If you have 60 and you stay at 60, means that you could have done 80 or 90. ![]() Originally posted by rogermorse:Overlay will always decrease your fps. ![]()
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Houzz lighting order1/20/2024 ![]() Buy the online from Houzz today, or shop for other Kitchen Cabinetry for sale. For orders in rustic maple, knots may be in locations that affect placement of decorative hardware.Discover Pinterest’s 10 best ideas and inspiration for Schuler cabinets. Drawer fronts maintain slab design with horizontal grain direction. Door and drawer front are constructed from 3/4″ thick solid wood with eased profile on all edges. ![]() Boardwalk Schuler Cabinetry At Lowes.Overview Plywood flat center panel Cabinetry available in Cherry and Maple Available in over 90 finish combinations Finished with superiority that combines modern technology and handcrafted artistry for a durable and beautiful cabinet Door sample cost is refundable with purchase of Schuler kitchen at Lowe's CA Residents: Prop 65 Warning (s)Now Selected: Maple. Customers can choose from a range of cabinet styles, colors, hardware, and more. The Schuler Cabinets Catalog is a comprehensive resource that offers a wide variety of options for the kitchen, bathroom, and other areas of the home. JBy admin Filed Under Kitchen Cabinets No Comments Schuler cabinets at lowe s cabinetry storage dalton vertical lift and stay cabinet why boardwalk kitchen renovation design farmhouse knotty alder cappuccino new rustic offers the most flexible options flexibleoptions moremods thananyoneelse our favorite ideas austin wood works inc durham 14 5 in w x 17. Discover (and save!) your own Pins on Pinterest Now you don't have to choose between style you love and the quality,This Pin was discovered by Brandi Stallman. This style is available in a wide variety of looks to meet any décor need.Schuler has a unique blend of premium features, superior quality and custom flexibility that enable you to create a beautifully designed, well-organized home, perfectly suited to your …Schuler Cabinetry, Waconia, Minnesota. Full overlay styles are set in front of the face frame and are slightly oversized so they overlap or “overlay” the opening of the cabinet. See more ideas about door styles, lowes kitchen cabinets, cabinetry.Full Overlay Doors. Schuler Boardwalk maple, Appaloosa finish, Granite Uba Tuba, composite granite sink, 16x16 Sardinia ceramic tile, ceramic and glass backsplash, stainless steelExplore Schuler Cabinetry's board "Cherry Door Styles", followed by 858 people on Pinterest. Custom design solutions and unparalleled, heirloom furniture quality cabinets for kitchens & bathrooms.Discover Pinterest’s 10 best ideas and inspiration for Schuler cabinets. Hardware Premium kitchen cabinetry at Lowes.
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New game of life game board1/20/2024 ![]() Most elements in the game are related to real-world elements and systems for instance, the game has options to choose between an educational path or a working path. capitalist world – A world mainly running based on a private economic system. The most fascinating part I really am addicted to this game is the ideology of portraying real-life situations during the gameplay of the alternative life in the (virtual) U.S. After that, players count their money, and the winner goes to whoever has the most money in the game. They continue playing the game by purchasing stuff, changing careers, and having a family and babies until they all end the game by reaching the retirement section. In every turn, players roll a die and move, then do the task given in the tile. Then, the game uses dice to present the number of tiles players must move in their turn. Players first need to choose which path they want to achieve, between going to college with debt or to the workplace with the inability to select some jobs for the whole game. The game ruleset is simple to understand. It consists of 4 loops of living – education, work, family, and retirement – where players need to survive in the game world to be the wealthiest man at the end. ![]() “The Game of Life” board game version 2021 is a branded-new version. Plenty of versions continually have developed and released until the present by altering and depicting the concept of society and technology. It portrayed life in a board game pattern – dice, money, pawns, and pathway. ![]() ![]() Reuben Klamer and Bill Markham are the two designers to create the game. The modern version of the game was released in 1960, after the original 100 years. It was not a board game but a checkerboard to represent life. To elaborate on the background of the game, The Game of Life was first established in 1860 by Milton Bradley. Have you ever thought about how games can deliver ideas of contemporary society? I bet that “The Game of Life” board game is one of those kinds to represent an actual society which is fun, enjoyable, and sometimes a bit scary to see what things future hold. ![]()
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![]() ![]() The PD-1/PD-L1 signaling pathway is one of the self-protection mechanisms of tumors against the endogenous immune response ( Taube et al., 2012). Moreover, the most successfully developed ICB therapy is anti–PD-1/PD-L1 therapy, since atezolizumab, nivolumab, and pembrolizumab have been approved for NSCLC ( Ribas and Wolchok, 2018). Several inhibitory immunoreceptors, including but not limited to CTLA-4, PD-1, TIM3, and LAG3, have been studied in some solid tumors in the past decades. Encouragingly, immune checkpoint blockade (ICB) immunotherapy had changed the landscape for treating advanced NSCLC, with a more durable response than targeted therapy and chemotherapy. However, tumor heterogeneity inevitably leads to resistance of targeted therapies from multiple mechanisms ( Tsui et al., 2018). Over the past few years, the introduction of the epidermal growth factor receptor (EGFR), tyrosine kinase inhibitors (TKIs), and anaplastic lymphoma kinase (ALK)-based target therapy dramatically improved the therapeutic efficacy for lung cancer patients with specific gene mutations ( Califano et al., 2017 Hida et al., 2017 Peters et al., 2017 Kiura et al., 2018 Novello et al., 2018). Non–small cell lung cancer (NSCLC) that accounts for almost 85 percent of total lung cancer patients is still the leading cause of cancer-related mortality, especially in those with advanced disease ( Sui et al., 2018 Seigel et al., 2017). ![]() Furthermore, singleton frequency may help us select patients who are sensitive to anti–PD-L1 immunotherapy. ![]() Our study demonstrated that efficient anti–PD-L1 therapy could reshape the TCR repertoire for antitumor patients. Two patterns of TCR changes among patients who received PD-L1–targeted immunotherapy were observed.Ĭonclusions: Deep sequencing of the T-cell receptors confirmed the existence of CD8 + PD-1high T cells with an exhaustion phenotype in Chinese NSCLC patients. The percentage of CD8 + PD-1 high terminal exhausted T cells declined in the response group after the PD-L1 blockade. Unlike the progression group, the diversity of TCR repertoire and singletons in the TCRβ pool increased over time with atezolizumab administration, and the TCR repertoire dynamically changes in the response group. Results: Clonal expansion with high PD-1 expression was detected in all patients’ peripheral CD8 + T cells before the treatment of atezolizumab. Diversity, clonality, and similarity of TCR have been calculated before and after treatment in both groups. T-cell receptor (TCR)-β chains of CD8 + T cells were analyzed by next-generation sequencing (NGS) at the deep level. Fresh peripheral blood mononuclear cells (PBMCs) from patients were stained with antihuman CD3, CD8, and PD-1 antibodies for flow cytometry analysis. Patients were classified into a response or progression group according to response evaluation criteria in solid tumors (RECIST) 1.1. Methods: In a prospective cohort with 12 Chinese advanced NSCLC patients who received atezolizumab 1,200 mg every 3 weeks as a second-line treatment, blood samples were obtained before and 6 weeks after atezolizumab initiation, and when disease progression was confirmed. However, associated with T-cell regulation, the immunomodulatory effect of PD-L1 blockade and its biomarker in peripheral immunity remains elusive. 5Zhejiang-California International Nano-Systems Institute, Zhejiang University, Hangzhou, Chinaīackground: Atezolizumab, a high-affinity engineered human anti–PD-L1 antibody, has produced a clinical benefit for patients with advanced non–small-cell lung cancer (NSCLC).4Hangzhou ImmuQuad Biotechnologies, LLC, Hangzhou, China.3Department of Human Genetics, University of Chicago, Chicago, IL, United States.2Laboratory of Cancer Biology, Institute of Clinical Science, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.1Department of Medical Oncology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.Jin Sheng 1,2 † Huadi Wang 1,2 † Xiao Liu 3 Yunyun Deng 4 Yingying Yu 4 Pengfei Xu 4 Jiawei Shou 1,2 Hong Pan 1,2 Hongsen Li 1,2 Xiaoyun Zhou 1 Weidong Han 1,2 Tao Sun 4,5* Hongming Pan 1* Yong Fang 1* ![]() |